New lipid formulation of amphotericin B: spectral and microscopic analysis

Study of the toxicity of a new lipid complex formulation of amphotericin B.

OBJECTIVES The aim of this study was to evaluate the toxicity of a new lipid complex formulation of amphotericin B (LC-AmB) produced by a simple process. METHODS Toxicity was evaluated after daily administration for 21 consecutive days in female CD1 mice. Doses of LC-AmB up to 20 mg/kg were used, and compared with Fungizone at 0.5 mg/kg and Abelcet at 10 mg/kg. Acute toxicity after a single b...

formulation and in vitro characterization of amphotericin b

Controlled trials of amphotericin B lipid complex.

because it occurred in the midst of the usual seasonal increase in the number of cases of enteroviral meningitis together with cases of herpes simplex virus 1 (HSV-1) encephalitis, which occurs sporadically throughout the year. HSV-1 encephalitis may be differentiated from WNE by the presence of focal abnormalities on the electroencephalogram and/or on CT/MRI scans. Most cases of enteroviral me...

Two doses of a lipid formulation of amphotericin B for the treatment of Mediterranean visceral leishmaniasis.

To evaluate the efficacy of a short course of a lipid formulation of amphotericin B (L-AmB) for the treatment of Mediterranean visceral leishmaniasis (VL), an open prospective study was conducted. Forty-one children with parasitologically confirmed leishmaniasis received L-AmB, 10 mg/kg daily for 2 days. The comparison groups were 30 children who, in a previous study, were treated with L-AmB, 4...

Treatment of mucosal leishmaniasis with a lipid formulation of amphotericin B.

M/78 Palate Y (5 years earlier) CRF, AVR 2160 36 Cure 20 days/10 months M/76 Palate/oropharynx Y (1 years earlier) CRF 2064 48 Cure 13 days/14 months M/54 Nose Y (1 years earlier) ARF 2600 42 Cure 16 days/7 months M/72 Larynx Y (2 years earlier) ARF 2000 35 Cure 15 days/13 months F/55 Nose/palate Y (1 years earlier) ARF 2016 42 Cure 17 days/9 months Mean ... ... ... 2168 40.6 ... 16 days/6.6 mo...